Gaining three places on last year, ETH Zurich jumps into the number nine spot, from 12th in 2014.
Its sister institute, the Ecole Polytechnique Fédérale de Lausanne (EPFL), also rises three places to number 14.
The two Swiss establishments are renowned for their engineering and scientific programmes and regularly rank highly in education guides.
The new QS (Quacquarelli Symonds) rankings mean ETH Zurich is the best university in continental Europe, with only institutions from the UK and US ahead of it in the table.
The guide praised its programmes for providing “a solid scientific foundation combined with outstanding all-round skills”, as well as its international outlook and “excellent teaching and research infrastructure”.
Of EPFL the report said it “has evolved into a top-ranked research and teaching institution that attracts some of the best intellects in the world”.
For the fourth year running the Massachusetts Institute of Technology (MIT) takes the top spot, while Harvard climbs two places to second, followed by the University of Cambridge in the UK and Stanford University in the US tying on third.
In addition to the two federal institutes of technology, four Swiss universities have made the top 150 this year – Zurich (85th), Geneva (89th), Basel (139th) and Lausanne (143rd)
Now in its 12th edition, the QS World University Rankings aims to help students make informed comparisons of leading universities around the world.
The methodology is based on six performance indicators over four areas: research, teaching, employability and internationalization.
Read the full QS World University Rankings 2015/15 here.