Froome is one of three former winners at this year's event, which runs until Sunday.
For many contenders Romandie is an early preparatory race ahead of July's Tour de France and defending Tour champion Froome will be joined by last year's Tour runner-up Nairo Quintana with top French hopes Thibaut Pinot and Romain Bardet also taking part.
Also on the start line will be surprise defending champion Ilnur Zakarin, who finished a strong fifth in Liege on Sunday, and 2010 winner Simon Spilak of Slovenia.
Romandie starts with a 3.95km prologue in La Chaux-de-Fonds that will unlikely provide any major time gaps between the main contenders but will do enough to create an early general classification.
However the cold and possible snow could be a factor during the early days of racing.
MeteoSuisse is forecasting snow for La Chaux-de-Fonds on Tuesday and temperatures no higher than four degrees. The sun should emerge as the week progresses but temperatures will remain low.
Already last month, stages had to be cancelled at both Paris-Nice and Tirreno-Adriatico due to snow creating dangerous conditions while Sunday's Liege-Bastogne-Liege one-day classic course was altered after the race had begun in order to avoid treacherous road surfaces caused by snowfall.
The stage most at risk, perhaps, will be Thursday's first summit finish at Morgins, although that is only 1,350-metres above sea-level.
A 15km time-trial follows on Friday before the crucial stage on Saturday that includes two ascents of the first category Col de la Croix climb, the second time being up to the finish.
Although this race comes two-and-a-half months before the Tour, it has in the recent past provided a good gauge as to the form of Grand Boucle hopefuls.
Australian Cadel Evans in 2011, Bradley Wiggins the next year and his British compatriot Froome in 2013 all won in Romandie before adding Tour glory.
Last year Froome seemed set to win Romandie for the third year in a row but produced an uncharacteristically poor final stage time-trial before settling for third overall, 35sec behind Zakarin.
Although he was far from flying in Liege — he finished 112th more than ten minutes behind his Sky team-mate and winner Wout Poels — he was in good shape earlier in the year when winning the Herald Sun Tour in Australia in February.
Colombian Quintana was running well in March when he won the Tour of Catalonia but was only third earlier this month behind Spain's Alberto Contador and another Colombian Sergio Henao in the Basque Country.
Pinot has also enjoyed success this year, in last month's Criterium International, while also managing top five finishes in the Algarve, the Basque Country and Tirreno-Adriatico.