The Swiss list now has 108 names on it, a statement said, adding that the expanded travel ban would now extend to Finance Minister Mohammad Al-Jleilati and Economy Minister Nidal Mohammad Al-Shaar.
The other officials targeted on Monday include chief of staff, Fahid Al-Jassim, for his involvement in violence in the flashpoint city of Homs and his deputy Ibrahim Al Hassan.
Switzerland also added 19 company names to the list bringing to 38 the total number of enterprises sanctioned.
They include television channel Press TV Cham, which "participates in campaigns of disinformation and incitement to violence against demonstrators" in Syria, the Al Watan newspaper, and several banks and oil firms.
Activists say more than 6,000 have been killed since the start of the anti-regime uprising on March 15th, 2011.