In a statement, the attorney general's office alleged that the bank and a former employee "played a decisive role" in concealing the proceeds from activities of "The Office", a criminal organisation Karimova is accused of setting up.
Lombard Odier said in a statement: "The allegations are unfounded, without merit and are firmly rejected by the bank."
Karimova, daughter of the late Islam Karimov, and an Uzbek telecoms executive were indicted in Switzerland last year in a vast case of corruption, fraud and organised crime.
In 2020, Karimova was sentenced to 13 years in prison in Uzbekistan for embezzlement and extortion.
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